Clomiphene Citrate 25mg

60,00 $

Active ingredient: Clomiphene citrateType: Selective estrogen receptor modulatorForm: Oral (pills)

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Clomiphene citrate is an antiestrogen belonging to the triphenylethylene group. It is classified as selective estrogen receptor modulator with mixed agonist and antagonistic properties This means that in certain tissues they block the action of estrogen by binding to receptors, while there is an exception – the  bone tissue, where, on the contrary, it. activates estrogen receptors, and its useful feature to prevent osteoporosis.

Mechanism of action

In men, both drugs act as antiestrogens in their ability to interfere with the negative feedback of estrogens to the hypothalamus and stimulate increased production of GnRH (gonadoliberin), which increase the production of LH and FSH hormones by the pituitary gland, triggering the synthesis of testosterone and sperm in the testicles.

Clomiphene  acts on estrogen receptors in the pituitary gland and ovaries. By binding the estrogen receptors in the pituitary gland, clomiphene breaks the negative feedback mechanism, i.e. if usually estrogens, acting on the pituitary gland, reduce the production of FSH and LH, then when taking clomiphene this does not happen. Clomiphene does not directly affect the level of estrogen in the blood.Thus, clomiphene acts as an antagonist of estrogens and eliminates their inhibitory effect on the hypothalamus and pituitary gland, contributing to a more rapid restoration of their function.


  • Blocking estrogen receptor (mostly active in brain)
  • Increase production of endogenous testosterone(as the part of PCT or anti-age therapy)
  • Strengthens bones
  • Prevents the estrogen induced gynecomastia

Side effects

  • Breast tenderness or discomfort
  • Headache
  • Nausea
  • Diarrhea
  • Flushing
  • Blurred vision or other visual disturbances
  • Note that Clomiphene side effects are very rare


  • Half-life: 5-6 days
  • Frequency of intake: 1 time day


  • Hypersensitivity to clomiphene citrate or components of the formulation
  • Pregnancy
  • Breastfeeding
  • History of hepatic impairment
  • Hepatic disease
  • Abnormal uterine bleeding
  • Uncontrolled adrenal dysfunction
  • Non-PCOS related ovarian cyst
  • Organic intracranial lesions
  • Uncontrolled thyroid disease
  • Pituitary tumor

How to store

  • Keep away from children
  • Keep in a cool, dry place, away from direct sunlight
  • Store at room temperature
  • Do not use after the expiry date

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